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Eplasty. 2015 Mar 26;15:e10. eCollection 2015.

Hair Regeneration Treatment Using Adipose-Derived Stem Cell Conditioned Medium: Follow-up With Trichograms.

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  • 1Cherry-Blossom Plastic and Regenerative Surgery, Tokyo, Japan; and Department of Plastic and Reconstructive Surgery, Kyorin University, Tokyo, Japan.

Abstract

OBJECTIVE:

Adipose-derived stem cells secrete various growth factors that promote hair growth. This study examined the effects of adipose-derived stem cell-conditioned medium on alopecia.

METHODS:

Adipose-derived stem cell-conditioned medium was intradermally injected in 22 patients (11 men and 11 women) with alopecia. Patients received treatment every 3 to 5 weeks for a total of 6 sessions. Hair numbers were counted using trichograms before and after treatment. A half-side comparison study was also performed in 10 patients (8 men and 2 women).

RESULTS:

Hair numbers were significantly increased after treatment in both male (including those without finasteride administration) and female patients. In the half-side comparison study, the increase in hair numbers was significantly higher on the treatment side than on the placebo side.

CONCLUSION:

Treatment using adipose-derived stem cell-conditioned medium appears highly effective for alopecia and may represent a new therapy for hair regeneration.

KEYWORDS:

adipose-derived stem cells; alopecia; conditioned medium; half-side comparison study; trichograms

PMID:
25834689
PMCID:
PMC4379938
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