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J Nutr. 2015 Apr;145(4):672-80. doi: 10.3945/jn.114.206029. Epub 2015 Feb 4.

Glucagon-like peptide 1 interacts with ghrelin and leptin to regulate glucose metabolism and food intake through vagal afferent neuron signaling.

Author information

1
Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, Davis, CA; and Department of Nutrition and Physiology and Ingestive Behavior, AgroParisTech, Paris, France.
2
Department of Nutrition and Physiology and Ingestive Behavior, AgroParisTech, Paris, France.
3
Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, Davis, CA; and heraybould@ucdavis.edu.

Abstract

Emerging evidence has suggested a possible physiologic role for peripheral glucagon-like peptide 1 (GLP-1) in regulating glucose metabolism and food intake. The likely site of action of GLP-1 is on vagal afferent neurons (VANs). The vagal afferent pathway is the major neural pathway by which information about ingested nutrients reaches the central nervous system and influences feeding behavior. Peripheral GLP-1 acts on VANs to inhibit food intake. The mechanism of the GLP-1 receptor (GLP-1R) is unlike other gut-derived receptors; GLP-1Rs change their cellular localization according to feeding status rather than their protein concentrations. It is possible that several gut peptides are involved in mediating GLP-1R translocation. The mechanism of peripheral GLP-1R translocation still needs to be elucidated. We review data supporting the role of peripheral GLP-1 acting on VANs in influencing glucose homeostasis and feeding behavior. We highlight evidence demonstrating that GLP-1 interacts with ghrelin and leptin to induce satiation. Our aim was to understand the mechanism of peripheral GLP-1 in the development of noninvasive antiobesity treatments.

KEYWORDS:

food intake; ghrelin; glucagon-like peptide 1; leptin; vagal afferent neurons

PMID:
25833771
PMCID:
PMC4381768
DOI:
10.3945/jn.114.206029
[Indexed for MEDLINE]
Free PMC Article

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