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Endocrinology. 2015 Jul;156(7):2461-9. doi: 10.1210/en.2014-1598. Epub 2015 Apr 1.

Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice.

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Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.


Increasing evidence indicates that brown adipose tissue (BAT) transplantation enhances whole-body energy metabolism in a mouse model of diet-induced obesity. However, it remains unclear whether BAT also has such beneficial effects on genetically obese mice. To address this issue, we transplanted BAT from C57/BL6 mice into the dorsal subcutaneous region of age- and sex-matched leptin deficient Ob/Ob mice. Interestingly, BAT transplantation led to a significant reduction of body weight gain with increased oxygen consumption and decreased total body fat mass, resulting in improvement of insulin resistance and liver steatosis. In addition, BAT transplantation increased the level of circulating adiponectin, whereas it reduced the levels of circulating free T3 and T4, which regulate thyroid hormone sensitivity in peripheral tissues. BAT transplantation also increased β3-adrenergic receptor and fatty acid oxidation related gene expression in subcutaneous and epididymal (EP) white adipose tissue. Accordingly, BAT transplantation increased whole-body thermogenesis. Taken together our results demonstrate that BAT transplantation may reduce obesity and its related diseases by activating endogenous BAT.

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