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Drug Res (Stuttg). 2016 Jan;66(1):23-7. doi: 10.1055/s-0035-1548764. Epub 2015 Apr 1.

Evaluation of Anti-inflammatory Activity of Seeds of Phalaris canariensis.

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Departamento de Alimentos, Escuela Nacional de Ciencias Biologicas-IPN, Carpio S/N, Mexico D.F.
Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingenieria Quimica e Industrias extractivas, Instituto Politecnico Nacional, Nacional S/N, Unidad Profesional Adolfo Lopez Mateos, Mexico D.F.


Chloroform extract (ALC) from the seeds of Phalaris canariensis were assayed for antiinflammatory activity by carrageenan-induced oedema, cotton pellets-induced granuloma, histamine-induced inflammation, croton oil-induced oedema, activity of myeloperoxidase (MPO), adjuvant-induced arthritis, quantification of TNFα, IL-1β, PGE2 and LTB4 and nitric oxide (NO) assay. ALC exhibited significant anti-inflammatory activity in different chemically-induced edemas in a dose dependent manner. In the chronic model cotton pellets-induced granuloma showed decreased formation of granuloma tissue. Also caused inhibition of ear inflammation edema and influx of polymorphonuclear cells, as evidence by a decrease in ear thickness and reduced myeloperoxidase activity and inhibit mediators of inflammation as TNFα, IL-1β, PGE2 and LTB4. When RAW 264.7 macrophages were treated with ALC together with LPS a significant inhibition of NO production was detected. These data provide evidence for antiinflammatory effect of P. canariensis by mechanisms that involve a reduced neutrophil influx and decreased production of inflammatory cytokines.

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