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Spine J. 2015 Jul 1;15(7):1593-601. doi: 10.1016/j.spinee.2015.03.039. Epub 2015 Mar 28.

Fat infiltration of paraspinal muscles is associated with low back pain, disability, and structural abnormalities in community-based adults.

Author information

1
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 99 Commercial Rd, Prahran, VIC, Australia 3004; Baker IDI Heart and Diabetes Institute, Commercial Rd, 99 Commercial Rd, Prahran, VIC, Australia 3004. Electronic address: Andrew.Teichtahl@monash.edu.
2
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 99 Commercial Rd, Prahran, VIC, Australia 3004.
3
MRI Department, Healthcare Imaging Services, Epworth Hospital, 89 Bridge Rd, Richmond, VIC, Australia, 3121; Department of Medicine, Central Clinical School, Monash University, 99 Commercial Rd, Prahran, VIC, 3004.

Abstract

BACKGROUND CONTEXT:

Low back pain and disability are major public health problems and may be related to paraspinal muscle abnormalities, such as a reduction in muscle size and muscle fat content.

PURPOSE:

The aim of this study was to examine the associations between paraspinal muscle size and fat content with lumbar spine symptoms and structure.

STUDY DESIGN/SETTING:

This was a community-based magnetic resonance imaging (MRI) cohort study.

PATIENT SAMPLE:

A total of 72 adults not selected on the basis of low back pain were included in the study.

OUTCOME MEASURES:

The outcomes measured were lumbar modic change and intervertebral disc height. Pain intensity and disability were measured from the Chronic Pain Grade Questionnaire at the time of MRI.

METHODS:

The cross-sectional area (CSA) and amount of fat in multifidus and erector spinae (high percentage defined by >50% of muscle) were measured, and their association with outcome was assessed.

RESULTS:

Muscle CSA was not associated with low back pain/disability or structure. High percentage of fat in multifidus was associated with an increased risk of high-intensity pain/disability (odds ratio [OR], 12.6; 95% confidence interval [CI], 2.0-78.3; p=.007) and modic change (OR, 4.3; 95% CI, 1.1-17.3; p=.04). High fat replacement of erector spinae was associated with reduced intervertebral disc height (β=-0.9 mm; 95% CI, -1.4 to -0.3; p=.002) and modic change (OR, 4.9; 95% CI, 1.1-21.9; p=.04).

CONCLUSIONS:

Paraspinal fat infiltration, but not muscle CSA, was associated with high-intensity pain/disability and structural abnormalities in the lumbar spine. Although cause and effect cannot be determined from this cross-sectional study, longitudinal data will help to determine whether disabling low back pain and structural abnormalities of the spine are a cause or result of fat replacement of paraspinal muscles.

KEYWORDS:

Disability; Fat; Intervertebral disc; Low back pain; Lumbar; Modic; Muscle

PMID:
25828477
DOI:
10.1016/j.spinee.2015.03.039
[Indexed for MEDLINE]

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