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Intern Med J. 2015 Apr;45(4):451-3. doi: 10.1111/imj.12712.

Potential role of coenzyme Q10 in facilitating recovery from statin-induced rhabdomyolysis.

Author information

1
Department of Cardiology, St Vincent's Hospital, Darlinghurst, New South Wales, Australia; St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia; Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.

Abstract

Rhabdomyolysis is a rare, but serious complication of statin therapy, and represents the most severe end of the spectrum of statin-induced myotoxicity. We report a case where coenzyme Q10 facilitated recovery from statin-induced rhabdomyolysis and acute renal failure, which had initially persisted despite statin cessation and haemodialysis. This observation is biologically plausible due to the recognised importance of coenzyme Q10 in mitochondrial bioenergetics within myocytes, and the fact that statins inhibit farnesyl pyrophosphate production, a biochemical step crucial for coenzyme Q10 synthesis. Coenzyme Q10 is generally well tolerated, and may potentially benefit patients with statin-induced rhabdomyolysis.

KEYWORDS:

coenzyme Q10; lipid; renal failure; rhabdomyolysis; statin

PMID:
25827512
DOI:
10.1111/imj.12712
[Indexed for MEDLINE]

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