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Kidney Int. 2015 Apr;87(4):680-2. doi: 10.1038/ki.2015.13.

Take my breath away: necrosis in kidney transplants kills the lungs!

Author information

1
1] Inflammation Research Center, VIB, Ghent, Belgium [2] Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
2
Clinic for Nephrology and Hypertension, Christian-Albrechts-University Kiel, Kiel, Germany.

Abstract

Necrosis is not only a regulated process, it is an interconnected molecular network allowing different genetically encoded forms that are more or less immunogenic. Zhao et al. elegantly illustrate this concept, underscore the need for combination therapy to successfully interfere with regulated necrosis, and identify the role of regulated necrosis in the pathophysiology of remote lung injury.

PMID:
25826542
DOI:
10.1038/ki.2015.13
[Indexed for MEDLINE]
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