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Oncotarget. 2015 Apr 30;6(12):10658-66.

Expression and clinicopathological significance of FSIP1 in breast cancer.

Author information

1
Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Hospital of Dalian Medical University, Dalian, China.
2
Department of Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
3
Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, China.
4
Shengjing Hospital, China Medical University, Shenyang, China.
5
Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China.

Abstract

AIM:

To investigate the clinicopathological significance of the expression of fibrous sheath interacting protein 1 (FSIP1) in breast cancer, serum samples, and wound fluid from patients with breast cancer.

METHODS:

Wound fluid and serum samples from female patients with primary breast cancer, recurrent and metastatic breast cancer, and benign tumors were analyzed for FSIP1 expression using ELISA. 286 paraffin-embedded surgical specimens from breast cancer patients with at least 5 years of follow-up were included for FSIP1 expression assay using immunohistochemistry.

RESULTS:

Expression of FSIP1 protein was significantly higher in breast cancer tissues compared to tumor-adjacent tissues (p = 0.001). Strong correlation was observed between FSIP1 expression and human epidermal growth factor receptor 2 (Her-2) or Ki67 expression in breast cancer (p = 0.027 and 0.002, respectively). Similarly, serum level of FSIP1 was higher in patients with recurrent and metastatic breast cancer compared to that of primary breast cancer (7, 713 ± 3, 065 vs. 4, 713 ± 3, 065 pg/ml, p = 0.003). Finally, patients with high FSIP1 expression showed a worse post-operative disease-specific survival (p = 0.024).

CONCLUSION:

FSIP1 may play an important role in the tumorigenesis and invasion of breast cancer and is a potential biomarker for breast cancer diagnosis or prognosis.

KEYWORDS:

FSIP1; breast cancer; metastasis; prognosis

PMID:
25826084
PMCID:
PMC4496383
DOI:
10.18632/oncotarget.3381
[Indexed for MEDLINE]
Free PMC Article

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