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Toxins (Basel). 2015 Mar 27;7(4):1079-101. doi: 10.3390/toxins7041079.

Chlorotoxin: a helpful natural scorpion peptide to diagnose glioma and fight tumor invasion.

Dardevet L1,2,3, Rani D1,2, Aziz TA4,5,6,7, Bazin I8, Sabatier JM9, Fadl M7, Brambilla E2,10, De Waard M11,12,13,14.

Author information

1
Grenoble Neuroscience Institute, Inserm U836, Team 3, Chemin Fortuné Ferrini, Bâtiment Edmond Safra, 38042 Grenoble Cedex 09, France. EBrambilla@chu-grenoble.fr.
2
Science Technology Health, Université Joseph Fourier, BP53, 38041 Grenoble, France. EBrambilla@chu-grenoble.fr.
3
Labex Ion Channel Science and Therapeutics, 660 route des lucioles, 06560 Valbonne, France. EBrambilla@chu-grenoble.fr.
4
Grenoble Neuroscience Institute, Inserm U836, Team 3, Chemin Fortuné Ferrini, Bâtiment Edmond Safra, 38042 Grenoble Cedex 09, France. mahmoudfs2000@yahoo.com.
5
Science Technology Health, Université Joseph Fourier, BP53, 38041 Grenoble, France. mahmoudfs2000@yahoo.com.
6
Labex Ion Channel Science and Therapeutics, 660 route des lucioles, 06560 Valbonne, France. mahmoudfs2000@yahoo.com.
7
Zoology Department, Faculty of Science, Minia University, 61519 Minia, Egypt. mahmoudfs2000@yahoo.com.
8
Ecole des Mines d'Ales, 6 av de Clavieres, 30100 Ales Cedex, France. ingrid.bazin@mines-ales.fr.
9
Inserm UMR 1097, 163, Avenue de Luminy, 13288 Marseille Cedex 09, France. sabatier.jm1@libertysurf.fr.
10
Institut Albert Bonniot, Inserm U823, Rond-Point de la Chantourne, 38706 La Tronche Cedex, France. EBrambilla@chu-grenoble.fr.
11
Grenoble Neuroscience Institute, Inserm U836, Team 3, Chemin Fortuné Ferrini, Bâtiment Edmond Safra, 38042 Grenoble Cedex 09, France. michel.dewaard@ujf-grenoble.fr.
12
Science Technology Health, Université Joseph Fourier, BP53, 38041 Grenoble, France. michel.dewaard@ujf-grenoble.fr.
13
Labex Ion Channel Science and Therapeutics, 660 route des lucioles, 06560 Valbonne, France. michel.dewaard@ujf-grenoble.fr.
14
Smartox Biotechnology, 570 Rue de la Chimie, Bâtiment Nanobio campus, 38400 Saint-Martin d'Hères, France. michel.dewaard@ujf-grenoble.fr.

Abstract

Chlorotoxin is a small 36 amino-acid peptide identified from the venom of the scorpion Leiurus quinquestriatus. Initially, chlorotoxin was used as a pharmacological tool to characterize chloride channels. While studying glioma-specific chloride currents, it was soon discovered that chlorotoxin possesses targeting properties towards cancer cells including glioma, melanoma, small cell lung carcinoma, neuroblastoma and medulloblastoma. The investigation of the mechanism of action of chlorotoxin has been challenging because its cell surface receptor target remains under questioning since two other receptors have been claimed besides chloride channels. Efforts on chlorotoxin-based applications focused on producing analogues helpful for glioma diagnosis, imaging and treatment. These efforts are welcome since gliomas are very aggressive brain cancers, close to impossible to cure with the current therapeutic arsenal. Among all the chlorotoxin-based strategies, the most promising one to enhance patient mean survival time appears to be the use of chlorotoxin as a targeting agent for the delivery of anti-tumor agents. Finally, the discovery of chlorotoxin has led to the screening of other scorpion venoms to identify chlorotoxin-like peptides. So far several new candidates have been identified. Only detailed research and clinical investigations will tell us if they share the same anti-tumor potential as chlorotoxin.

PMID:
25826056
PMCID:
PMC4417956
DOI:
10.3390/toxins7041079
[Indexed for MEDLINE]
Free PMC Article

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