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Mol Cells. 2015 Apr;38(4):297-303. doi: 10.14348/molcells.2015.0020. Epub 2015 Mar 31.

Is acetylation a metabolic rheostat that regulates skeletal muscle insulin action?

Author information

1
Department of Orthopaedic Surgery, University of California, San Diego, CA, 92093, USA.
2
Biomedical Sciences Graduate Program, University of California, San Diego, CA, 92093, USA.

Abstract

Skeletal muscle insulin resistance, which increases the risk for developing various metabolic diseases, including type 2 diabetes, is a common metabolic disorder in obesity and aging. If potential treatments are to be developed to treat insulin resistance, then it is important to fully understand insulin signaling and glucose metabolism. While recent large-scale "omics" studies have revealed the acetylome to be comparable in size to the phosphorylome, the acetylation of insulin signaling proteins and its functional relevance to insulin-stimulated glucose transport and glucose metabolism is not fully understood. In this Mini Review we discuss the acetylation status of proteins involved in the insulin signaling pathway and review their potential effect on, and relevance to, insulin action in skeletal muscle.

KEYWORDS:

SIRT1/HDAC; acetyltransferase; deacetylase; insulin signaling; p300/CBP

PMID:
25824547
PMCID:
PMC4400303
DOI:
10.14348/molcells.2015.0020
[Indexed for MEDLINE]
Free PMC Article

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