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Antimicrob Agents Chemother. 2015;59(6):3627-9. doi: 10.1128/AAC.04945-14. Epub 2015 Mar 30.

In vitro antibacterial activity of AZD0914 against human Mycoplasmas and Ureaplasmas.

Author information

1
University of Alabama at Birmingham, Birmingham, Alabama, USA waiteskb@uab.edu.
2
University of Alabama at Birmingham, Birmingham, Alabama, USA.
3
Infection iMed, AstraZeneca Pharmaceuticals LP, Waltham, Massachusetts, USA.

Abstract

In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against Mycoplasma and Ureaplasma species. The activity of AZD0914 was comparable to that of levofloxacin and doxycycline against Mycoplasma genitalium and Mycoplasma pneumoniae. The AZD0914 MIC90 against Mycoplasma hominis was 8-fold greater than that for levofloxacin. The AZD0914 MIC90 against Ureaplasma species was 4-fold less than that for azithromycin and 8-fold less than that for levofloxacin and doxycycline.

PMID:
25824220
PMCID:
PMC4432128
DOI:
10.1128/AAC.04945-14
[Indexed for MEDLINE]
Free PMC Article

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