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Clin Med (Lond). 2015 Apr;15(2):130-4. doi: 10.7861/clinmedicine.15-2-130.

Cerebral involvement in IgG4-related disease.

Author information

1
Department of Gastroenterology, University College London Hospitals, London, UK;
2
Department of Radiology, University College London Hospitals, London, UK;
3
Department of Endocrinology, University College London Hospitals, London, UK;
4
Department of Respiratory Medicine, Barking, Havering and Redbridge University Hospitals, UK;
5
Department of Pathology, University College London Hospitals, London, UK;
6
The National Hospital for Neurology and Neurosurgery, London, UK;
7
Department of Gastroenterology, University College London Hospitals, London, UK george.webster@uclh.nhs.uk.

Abstract

IgG4-related disease is a recently recognised multi-system disease. Common organ involvement includes the pancreas, biliary tree and salivary glands. Central nervous system involvement has been infrequently reported. In a single-centre cohort of 84 patients, we report cerebral involvement in three (4%) patients. Details of cerebral involvement in these patients are outlined, including pituitary involvement in two patients and a diffuse autoimmune-like encephalopathy in the other.

KEYWORDS:

Autoimmune pancreatitis; IgG4-related disease; encephalopathy; hypophysitis

PMID:
25824063
DOI:
10.7861/clinmedicine.15-2-130
[Indexed for MEDLINE]

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