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Org Lett. 2015 Apr 17;17(8):1922-5. doi: 10.1021/acs.orglett.5b00608. Epub 2015 Mar 31.

Design, synthesis, and characterization of SO2-containing azabicyclo[3.n.1]alkanes: promising building blocks for drug discovery.

Author information

1
†Enamine, Ltd., Chervonotkatska 78, Kyiv 01103, Ukraine.
2
‡Department of Chemistry, National Taras Shevchenko University of Kyiv, Volodymyrska 64, Kyiv 01033, Ukraine.
3
§STC 'Institute for Single Crystals', NAS of Ukraine 60 Lenina Avenue, Kharkiv 61001, Ukraine.

Abstract

A set of novel SO2-containing azabicyclo[3.n.1]alkanes has been synthesized by the double-Mannich annulation of of the corresponding monocyclic S-ketones. These compounds have been rationally designed as 3D-shaped, conformationally restricted SO2-containing building blocks for drug discovery.

PMID:
25823962
DOI:
10.1021/acs.orglett.5b00608
[Indexed for MEDLINE]

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