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Philos Trans R Soc Lond B Biol Sci. 2015 May 19;370(1668). pii: 20140310. doi: 10.1098/rstb.2014.0310.

Brain/MINDS: brain-mapping project in Japan.

Author information

1
Laboratory for Marmoset Neural Architecture, Brain Science Institute RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan hidokano@brain.riken.jp hidokano@a2.keio.jp.
2
Laboratory for Cell Function Dynamics, Brain Science Institute RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan matsushi@brain.riken.jp.
3
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan kasaik-tky@umin.net.

Abstract

There is an emerging interest in brain-mapping projects in countries across the world, including the USA, Europe, Australia and China. In 2014, Japan started a brain-mapping project called Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS). Brain/MINDS aims to map the structure and function of neuronal circuits to ultimately understand the vast complexity of the human brain, and takes advantage of a unique non-human primate animal model, the common marmoset (Callithrix jacchus). In Brain/MINDS, the RIKEN Brain Science Institute acts as a central institute. The objectives of Brain/MINDS can be categorized into the following three major subject areas: (i) structure and functional mapping of a non-human primate brain (the marmoset brain); (ii) development of innovative neurotechnologies for brain mapping; and (iii) human brain mapping; and clinical research. Brain/MINDS researchers are highly motivated to identify the neuronal circuits responsible for the phenotype of neurological and psychiatric disorders, and to understand the development of these devastating disorders through the integration of these three subject areas.

KEYWORDS:

brain mapping by integrated neurotechnologies for disease studies; neuropsychiatric and neurodegenerative diseases; optogenetics; super-resolution microscopy; tissue clearing; transgenic non-human primates

PMID:
25823872
PMCID:
PMC4387516
DOI:
10.1098/rstb.2014.0310
[Indexed for MEDLINE]
Free PMC Article

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