Format

Send to

Choose Destination
Cerebellum. 2016 Apr;15(2):213-32. doi: 10.1007/s12311-015-0664-x.

Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias.

Author information

1
Department of Medical Education, Tokyo Medical University, Tokyo, Japan. mitoma@tokyo-med.ac.jp.
2
Department of Haematology, Nil Ratan Sircar Medical College, 138 A J C Bose Road, Kolkata, 700014, West Bengal, India.
3
Matrix Biology &Tissue Repair Research Unit, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, Wales, UK.
4
Department of General Medicine, College of Medicine & Sagore Dutta Hospital, 578 B T Road, Kamarhati-Kolkata, 700056, West Bengal, India.
5
Academic Department of Neurosciences, Royal Hallamshire Hospital, Sheffield, UK.
6
School of Medicine, University of Washington, 850 Republication, Seattle, WA, 98109, USA.
7
University Lyon 1, University Lyon, Rue Guillaume Paradin, 69372, Lyon Cedex 08, France.
8
INSERM, UMR-S1028, CNRS, UMR-5292, Neuro-Oncology and Neuro-Inflammation Team, 7, Lyon Neuroscience Research Center, Rue Guillaume Paradin, 69372, Lyon Cedex 08, France.
9
National Reference Centre for Paraneoplastic Neurological Diseases, Hospices Civils de Lyon, Hôpital Neurologique, 69677, Bron, France.
10
Hospices Civils de Lyon, Neuro-oncology, Hôpital Neurologique, 69677, Bron, France.
11
Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
12
Unité d'Etude du Mouvement, FNRS, Neurologie ULB-Erasme, 808 Route de Lennik, 1070, Brussels, Belgium.
13
Department of Neurology, University of Fukui Hospital, Fukui, Japan.
14
National Center of Neurology and Psychiatry, Tokyo, Japan.
15
Department of Neurology, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan.
16
Faculty of Nursing and Social Welfare Sciences, Fukui Prefectural University, Fukui, Japan.
17
Departments of Medicine and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Abstract

In the last few years, a lot of publications suggested that disabling cerebellar ataxias may develop through immune-mediated mechanisms. In this consensus paper, we discuss the clinical features of the main described immune-mediated cerebellar ataxias and address their presumed pathogenesis. Immune-mediated cerebellar ataxias include cerebellar ataxia associated with anti-GAD antibodies, the cerebellar type of Hashimoto's encephalopathy, primary autoimmune cerebellar ataxia, gluten ataxia, Miller Fisher syndrome, ataxia associated with systemic lupus erythematosus, and paraneoplastic cerebellar degeneration. Humoral mechanisms, cell-mediated immunity, inflammation, and vascular injuries contribute to the cerebellar deficits in immune-mediated cerebellar ataxias.

KEYWORDS:

Anti-GAD antibodies; Cerebellar ataxias; Gluten ataxia; Hashimoto’s encephalopathy; Miller Fisher syndrome; Paraneoplastic cerebellar degeneration; Primary autoimmune cerebellar ataxia; Systemic lupus erythematosus

PMID:
25823827
PMCID:
PMC4591117
DOI:
10.1007/s12311-015-0664-x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center