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Laryngoscope. 2015 Oct;125(10):2366-70. doi: 10.1002/lary.25259. Epub 2015 Mar 30.

Hearing function after intratympanic application of gadolinium-based contrast agent: A long-term evaluation.

Author information

1
Department of Otorhinolaryngology-Head and Neck Surgery, Ludwig-Maximilians-University of Munich, Munich, Germany.

Abstract

OBJECTIVES/HYPOTHESIS:

The aim of this study was to evaluate the long-term influence of intratympanic gadolinium-based contrast agent on hearing function in patients with possible Ménière's disease and normal auditory thresholds who were undergoing locally enhanced magnetic resonance imaging scans.

STUDY DESIGN:

Prospective observational cohort study in a tertiary referral university hospital ear, nose, and throat department.

METHODS:

Between 2009 and 2012, 17 patients with possible or probable Ménière's disease and a four-tone pure-tone average baseline of <25 dB were recruited for our study. Before undergoing intratympanic injection of gadolinium-based contrast agent, all patients underwent a complete audiological evaluation. The study population was then invited back after at least 6 months postinjection for a follow-up auditory evaluation. This consisted of comprehensive clinical and audiological tests on both sides and were evaluated according to the ototoxicity guidelines.

RESULTS:

A long-term evaluation of our study group revealed no significant difference in the air-conduction pure-tone average. Furthermore, no statistical difference at individual frequencies compared to baseline was found. There was no evidence of ototoxicity in the injected ear.

CONCLUSIONS:

Long-term hearing function assessment after intratympanic application of gadolinium-based agent showed no evidence of ototoxicity. The use of intratympanic gadolinium-based agent in the diagnosis of Ménièrés disease is currently a helpful tool, and seems to be a safe method, especially with regard to auditory function.

LEVEL OF EVIDENCE:

4.

KEYWORDS:

Gadolinium; Ménière's disease; hearing function; intratympanic application; long term

PMID:
25823415
DOI:
10.1002/lary.25259
[Indexed for MEDLINE]

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