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PLoS One. 2015 Mar 30;10(3):e0123265. doi: 10.1371/journal.pone.0123265. eCollection 2015.

High prevalence of nickel allergy in an overweight female population: a pilot observational analysis.

Author information

1
St Vincent Private Hospital, Dublin, Ireland.
2
Ospedale Pediatrico Bambino Gesu', Epidemiology and Biostatistics Unit, Rome, Italy.
3
Central Laboratory, Cardiology and Preventive Medicine Unit, Italian Red Cross, Rome, Italy.
4
Liver Unit, St Camillo-Forlanini Hospital, Rome, Italy.

Abstract

CONTEXT:

In our Allergy Unit, we incidentally observed that a low Nickel diet, prescribed for delayed allergy to Nickel sulfate, reduced body mass index (BMI) and waist circumference in overweight patients.

OBJECTIVES:

This pilot cross-sectional analysis was undertaken to compare the prevalence of Nickel allergy of overweight individuals versus the general population. We also had the chance to report the efficacy of a low Nickel diet on BMI and waist circumference in Nickel-sensitive overweight subjects.

METHODS:

Eighty-seven overweight subjects, with a BMI > 26 Kg/m2, were consecutively enrolled in a health prevention program, and screened for the presence of Nickel allergy. The enrolled population was mostly females (72/87) (82.8%). Forty-three overweight women and two men showed a Nickel allergy and started a low Nickel diet. After 6-months of dieting, 24 overweight allergic women could be traced and changes in BMI and waist circumference were calculated.

MAIN OUTCOME MEASUREMENTS:

Prevalence of Nickel allergy in overweight.

RESULTS:

Prevalence of Nickel allergy in overweight female was 59.7%, compared with a prevalence rate of 12.5% in the general population. A significant reduction in BMI was observed in 24 out of 43 overweight females with Nickel allergy after 24 weeks of a low Nickel diet. Relative to baseline, mean BMI decrease was 4.2 ± 0.5 (P < 0.001) and the mean decline in waist circumference was 11.7 ± 0.6 cm (P < 0.001).

CONCLUSIONS:

This pilot observational analysis showed a substantially higher prevalence of Nickel allergy among overweight females, especially those with metabolic syndrome and fatty liver disease. A normocaloric low Nickel diet was effective in reducing BMI in this population. Further research is strongly needed to confirm these preliminary findings.

PMID:
25822975
PMCID:
PMC4379055
DOI:
10.1371/journal.pone.0123265
[Indexed for MEDLINE]
Free PMC Article

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