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Bioconjug Chem. 2015 May 20;26(5):791-801. doi: 10.1021/acs.bioconjchem.5b00103. Epub 2015 Apr 16.

Guiding principles in the design of molecular bioconjugates for vaccine applications.

Author information

1
†Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, Michigan 48202, United States.
2
‡Department of Oncology, Wayne State University, Detroit, Michigan 48201, United States.
3
§Tumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States.
4
▼Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, United States.

Abstract

Antigen- and adjuvant-based bioconjugates that can stimulate the immune system play an important role in vaccine applications. Bioconjugates have demonstrated unique physicochemical and biological properties, enabling vaccines to be delivered to key immune cells, to target specific intracellular pathways, or to mimic immunogenic properties of natural pathogens. In this Review we highlight recent advances in such molecular immunomodulators, with an emphasis on the structure-function relationships that provide the foundation for rational design of safe and effective vaccines and immunotherapies.

PMID:
25822926
PMCID:
PMC4694040
DOI:
10.1021/acs.bioconjchem.5b00103
[Indexed for MEDLINE]
Free PMC Article

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