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Int J Food Sci Nutr. 2015;66(5):533-8. doi: 10.3109/09637486.2015.1024204. Epub 2015 Mar 30.

Effect of Lactobacillus plantarum NCU116 on loperamide-induced constipation in mice.

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State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang , China and.


Lactobacillus plantarum, as a probiotic, has many functional properties in human intestinal tract. This study examined the effects of L. plantarum NCU116 on loperamide-induced constipation in a mouse model. Loperamide (5 mg kg(-1)) was injected subcutaneously to induce constipation. Animals were divided to five groups: normal group, constipation group, constipation plus three doses of L. plantarum NCU116 groups (NCU116-L, 10(7) CFU/mL; NCU116-M, 10(8) CFU/mL; NCU116-H, 10(9) CFU/mL; respectively). Mice were treated with the probiotic for 15 d to assess the anti-constipation effects. Fecal parameters, intestinal transit ratio and the production of fecal short chain fatty acids, histological of colon and immunohistochemical in colonic interstitial cells of Cajal (ICC) by c-kit were all improved in L. plantarum NCU116-treated mice as compared to the constipation group. These results demonstrate that L. plantarum NCU116 enhanced gastrointestinal transit and alleviated in mice with loperamide-induced constipation.


Constipation; Lactobacillus plantarum NCU116; histological findings; loperamide; short chain fatty acids

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