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Nat Neurosci. 2015 May;18(5):718-27. doi: 10.1038/nn.3974. Epub 2015 Mar 30.

Synaptic diversity enables temporal coding of coincident multisensory inputs in single neurons.

Author information

1
1] Institut Pasteur, Unit of Dynamic Neuronal Imaging, Paris, France. [2] CNRS UMR 3571, Genes, Synapses and Cognition, Institut Pasteur, Paris, France.
2
1] Division of Neurophysiology, MRC National Institute for Medical Research, Mill Hill, London, UK. [2] Max Planck Institute of Neurobiology, Department Circuits - Computation - Models, Martinsried, Germany.
3
1] CNRS UMR 3571, Genes, Synapses and Cognition, Institut Pasteur, Paris, France. [2] Laboratory for Perception and Memory, Institut Pasteur, Paris, France.
4
1] Division of Neurophysiology, MRC National Institute for Medical Research, Mill Hill, London, UK. [2] Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.

Abstract

The ability of the brain to rapidly process information from multiple pathways is critical for reliable execution of complex sensory-motor behaviors, yet the cellular mechanisms underlying a neuronal representation of multimodal stimuli are poorly understood. Here we explored the possibility that the physiological diversity of mossy fiber (MF) to granule cell (GC) synapses in the mouse vestibulocerebellum may contribute to the processing of coincident multisensory information at the level of individual GCs. We found that the strength and short-term dynamics of individual MF-GC synapses can act as biophysical signatures for primary vestibular, secondary vestibular and visual input pathways. Most GCs receive inputs from different modalities, which, when coactivated, produced enhanced GC firing rates and distinct first spike latencies. Thus, pathway-specific synaptic response properties permit temporal coding of correlated multisensory inputs by single GCs, thereby enriching sensory representation and facilitating pattern separation.

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PMID:
25821914
PMCID:
PMC4413433
DOI:
10.1038/nn.3974
[Indexed for MEDLINE]
Free PMC Article

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