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Hum Brain Mapp. 2015 Jul;36(7):2417-31. doi: 10.1002/hbm.22781. Epub 2015 Mar 28.

Human pulvinar functional organization and connectivity.

Barron DS1,2, Eickhoff SB3,4, Clos M5,4, Fox PT1,6,7,8,9,10.

Author information

1
Research Imaging Institute, University of Texas Health Science Center at San Antonio, Texas, USA.
2
Yale University School of Medicine, New Haven, Connecticut, USA.
3
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
4
Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
5
Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
6
Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
7
Research Service, South Texas Veterans Health Care System, San Antonio, Texas, USA.
8
Department of Neurology, University of Texas Health Science Center, San Antonio, Texas, USA.
9
State Key Laboratory for Brain and Cognitive Sciences, University of Hong Kong, Hong Kong.
10
Neuroimaging Laboratory, Shenzhen University School of Medicine, Shenzhen, China.

Abstract

The human pulvinar is the largest thalamic area in terms of size and cortical connectivity. Although much is known about regional pulvinar structural anatomy, relatively little is known about pulvinar functional anatomy in humans. Cooccurrence of experimentally induced brain activity is a traditional metric used to establish interregional brain connectivity and forms the foundation of functional neuroimaging connectivity analyses. Because functional neuroimaging studies report task-related coactivations within a standardized space, meta-analysis of many whole-brain studies can define the brain's interregional coactivation across many tasks. Such an analysis can also detect and define variations in functional coactivations within a particular region. Here we use coactivation profiles reported in ∼ 7,700 functional neuroimaging studies to parcellate and define the pulvinar's functional anatomy. Parcellation of the pulvinar's coactivation profile identified five clusters per pulvinar of distinct functional coactivation. These clusters showed a high degree of symmetry across hemispheres and correspondence with the human pulvinar's cytoarchitecture. We investigated the functional coactivation profiles of each resultant pulvinar cluster with meta-analytic methods. By referencing existent neuroimaging and lesion-deficit literature, these profiles make a case for regional pulvinar specialization within the larger human attention-controlling network. Reference to this literature also informs specific hypotheses that can be tested in subsequent studies in healthy and clinical populations.

KEYWORDS:

attention; cognitive neuroscience; fMRI; functional anatomy; pulvinar

PMID:
25821061
PMCID:
PMC4782796
DOI:
10.1002/hbm.22781
[Indexed for MEDLINE]
Free PMC Article

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