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J Autoimmun. 2015 May;59:85-90. doi: 10.1016/j.jaut.2015.03.002. Epub 2015 Mar 26.

Significant association of periodontal disease with anti-citrullinated peptide antibody in a Japanese healthy population - The Nagahama study.

Author information

1
Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan; Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan. Electronic address: a0001101@kuhp.kyoto-u.ac.jp.
2
Department of Oral and Maxillofacial Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
3
Department of the Control for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
4
Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
5
The Lion Foundation for Dental Health, Tokyo 130-0004, Japan.
6
Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
7
Department of Health Informatics, Kyoto University School of Public Health, Kyoto 606-8501, Japan.
8
Department of Medical Ethics and Medical Genetics, Kyoto University School of Public Health, Kyoto 606-8501, Japan.
9
EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

Abstract

Anti-citrullinated peptide antibody (ACPA) is a highly specific autoantibody to rheumatoid arthritis (RA). Recent studies have revealed that periodontal disease (PD) is closely associated with RA and production of ACPA in RA. Analyses of associations between PD and ACPA production in a healthy population may deepen our understandings. Here, we analyzed a total of 9554 adult healthy subjects. ACPA and IgM-rheumatoid factor (RF) was quantified and PD status was evaluated using the number of missing teeth (MT), the Community Periodontal Index (CPI) and Loss of Attachment (LA) for these subjects. PD status was analyzed for its association with the positivity and categorical levels of ACPA and RF conditioned for covariates which were shown to be associated with PD, ACPA or RF. As a result, all of MT, CPI and LA showed suggestive or significant associations with positivity (p = 0.024, 0.0042 and 0.037, respectively) and levels of ACPA (p ≤ 0.00031), but none of the PD parameters were associated with those of RF. These association patterns were also observed when we analyzed 6206 non-smokers of the participants. The significant associations between PD parameters and positivity and levels of ACPA in healthy population support the fundamental involvement of PD with ACPA production.

KEYWORDS:

ACPA; Association study; Epidemiological study; Periodontal disease; RF; Rheumatoid arthritis

PMID:
25819755
DOI:
10.1016/j.jaut.2015.03.002
[Indexed for MEDLINE]
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