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Bioinformatics. 2015 Aug 1;31(15):2577-9. doi: 10.1093/bioinformatics/btv184. Epub 2015 Mar 29.

ExaML version 3: a tool for phylogenomic analyses on supercomputers.

Author information

1
Scientific Computing Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany and.
2
Scientific Computing Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany and Department of informatics, Institute of Theoretical Informatics, Karlsruhe Institute of Technology, Karlsruhe, Germany.

Abstract

MOTIVATION:

Phylogenies are increasingly used in all fields of medical and biological research. Because of the next generation sequencing revolution, datasets used for conducting phylogenetic analyses grow at an unprecedented pace. We present ExaML version 3, a dedicated production-level code for inferring phylogenies on whole-transcriptome and whole-genome alignments using supercomputers.

RESULTS:

We introduce several improvements and extensions to ExaML: Extensions of substitution models and supported data types, the integration of a novel load balance algorithm as well as a parallel I/O optimization that significantly improve parallel efficiency, and a production-level implementation for Intel MIC-based hardware platforms.

PMID:
25819675
PMCID:
PMC4514929
DOI:
10.1093/bioinformatics/btv184
[Indexed for MEDLINE]
Free PMC Article

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