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Cytokine. 2015 Aug;74(2):190-7. doi: 10.1016/j.cyto.2015.03.007. Epub 2015 Mar 25.

Insights into antiviral innate immunity revealed by studying hepatitis C virus.

Author information

1
Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC 27710, United States; Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States. Electronic address: stacy.horner@duke.edu.

Abstract

Experimental studies on the interactions of the positive strand RNA virus hepatitis C virus (HCV) with the host have contributed to several discoveries in the field of antiviral innate immunity. These include revealing the antiviral sensing pathways that lead to the induction of type I interferon (IFN) during HCV infection and also the importance of type III IFNs in the antiviral immune response to HCV. These studies on HCV/host interactions have contributed to our overall understanding of viral sensing and viral evasion of the antiviral intracellular innate immune response. In this review, I will highlight how these studies of HCV/host interactions have led to new insights into antiviral innate immunity. Overall, I hope to emphasize that studying antiviral immunity in the context of virus infection is necessary to fully understand antiviral immunity and how it controls the outcome of viral infection.

KEYWORDS:

Hepatitis C virus; Innate immunity; Interferon; MAVS; NS3/4A

PMID:
25819428
PMCID:
PMC4475425
DOI:
10.1016/j.cyto.2015.03.007
[Indexed for MEDLINE]
Free PMC Article

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