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J Dermatol. 2015 Jun;42(6):567-71. doi: 10.1111/1346-8138.12865. Epub 2015 Mar 26.

Red blood cell distribution width is increased in patients with psoriasis vulgaris: A retrospective study on 261 patients.

Author information

1
Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Seoul, South Korea.
2
Brain Korea 21 Plus Project for Medical Science, Seoul, South Korea.
3
Department of Environmental Medical Biology, Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, South Korea.
4
Department of Dermatology, National Health Insurance Service Ilsan Hospital, Goyang, South Korea.

Abstract

Circulating inflammatory cytokines and markers are increased in patients with psoriasis. Recent studies have shown that a higher red blood cell distribution width (RDW) is associated with disease activity in various disorders. Our objective was to investigate whether RDW is increased in psoriasis patients, and to evaluate its possible association with disease severity. We conducted a retrospective study of psoriasis patients seen in a university hospital in South Korea. Information about demographics, hematological parameters and disease severity were collected. Statistical analysis was performed using Student's t-test, multivariable logistic regression, Fisher's exact test and Spearman's rank correlation coefficient analysis as appropriate. A total of 261 psoriasis patients and 102 healthy controls were included in our study. The mean RDW value was significantly increased in psoriasis patients compared with healthy control (P = 0.037). Compared with mild psoriasis patients (Psoriasis Area and Severity Index [PASI], <7), moderate to severe patients (PASI, ≥7) showed significantly higher RDW values (P = 0.044). However, RDW did not show significant correlation with PASI (P = 0.358). When patients were divided into two groups according to their RDW value (<14.6% and ≥14.6%), the mean value of PASI was not significantly different (P = 0.219). Patients with psoriasis showed increased RDW values compared with healthy controls. It was also higher in the moderate and severe disease group than the mild group. Though this is only a pilot study, it is possible that RDW value can reflect the inflammatory status of psoriasis patients.

KEYWORDS:

C-reactive protein; Psoriasis Area Severity Index; erythrocyte sedimentation rate; inflammation; psoriasis vulgaris; red blood cell distribution width

PMID:
25819386
DOI:
10.1111/1346-8138.12865
[Indexed for MEDLINE]

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