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J Proteomics. 2015 Sep 8;127(Pt A):147-51. doi: 10.1016/j.jprot.2015.03.018. Epub 2015 Mar 26.

Indian proteomics efforts and human proteome project.

Author information

1
Institute of Bioinformatics, Bangalore 560066, India; Mazumdar Shaw Center for Translational Research, Bangalore 560099, India. Electronic address: ravi@ibioinformatics.org.

Abstract

The Draft Maps of Human Proteome published in two independent articles provide a catalogue of proteins encoded in the human genome including missing proteins, based on large scale mass spectrometric analysis. Six months later, a Tissue-based Human Proteome Map was published which includes a study of expression and distribution of human proteins across tissues and cells using specific antibodies. Independently, in an ongoing global effort - the Chromosome centric, and Biology and Disease centric Human Proteome Project (C-HPP and B/D-HPP) initiated by the Human Proteome Organization aims to study in-depth human proteins and their variants in terms of biology and disease in a chromosome centric manner. Under this initiative, a consortium formed among five Asian research teams including India aims to study Chromosome 12 encoded proteins and their disease context. Together, the group has recently published the first series of 3 papers giving the overall vision and the initial contributions. While one of the draft maps of the human proteome is largely contributed by an Indian team, Indian researchers have significant role in the other two initiatives as well. These efforts will be pursued further as more teams join and more disease and biology components get incorporated.

BIOLOGICAL SIGNIFICANCE:

This article focuses on the complexity and challenges of deciphering human proteome and contribution of Indian researchers in the human proteome projects, including the on-going C-HPP. This article is part of a Special Issue entitled: Proteomics in India.

KEYWORDS:

C-HPP; Human chromosomes; Human proteome; Mass spectrometry; Proteomics

PMID:
25818723
DOI:
10.1016/j.jprot.2015.03.018
[Indexed for MEDLINE]

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