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Biochim Biophys Acta. 2015 Apr;1855(2):248-53. doi: 10.1016/j.bbcan.2015.03.004. Epub 2015 Mar 24.

Fighting the force: Potential of homeobox genes for tumor microenvironment regulation.

Author information

1
Department of Surgery, Surgical Research Laboratory, UCSF, 1001 Potrero Ave, San Francisco, CA 94143, USA.
2
Department of Surgery, Center for Bioengineering and Tissue Regeneration, UCSF, 513 Parnassus Ave, San Francisco, CA 94143, USA.
3
Department of Surgery, Center for Bioengineering and Tissue Regeneration, UCSF, 513 Parnassus Ave, San Francisco, CA 94143, USA; Department of Anatomy, UCSF, San Francisco, CA, USA; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, CA, USA; UCSF Helen Diller Comprehensive Cancer Center, UCSF, San Francisco, CA, USA. Electronic address: Valerie.Weaver@ucsfmedctr.org.

Abstract

Tumor cells exist in a constantly evolving stromal microenvironment composed of vasculature, immune cells and cancer-associated fibroblasts, all residing within a dynamic extracellular matrix. In this review, we examine the biochemical and biophysical interactions between these various stromal cells and their matrix microenvironment. While the stroma can alter tumor progression via multiple mechanisms, we emphasize the role of homeobox genes in detecting and modulating the mechanical changes in the microenvironment during tumor progression.

KEYWORDS:

Extracellular matrix; Homeobox genes; Stiffness; Stromal cells; Tumor microenvironment

PMID:
25818365
PMCID:
PMC4433566
DOI:
10.1016/j.bbcan.2015.03.004
[Indexed for MEDLINE]
Free PMC Article

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