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Neurosci Lett. 2015 May 19;595:25-9. doi: 10.1016/j.neulet.2015.03.044. Epub 2015 Mar 25.

The role of the frontopolar cortex in manipulation of integrated information in working memory.

Author information

1
Department of Psychology, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 702-701, South Korea. Electronic address: ckim@knu.ac.kr.
2
Department of Psychology, New Mexico State University, Las Cruces, NM, USA; Department of Psychology, University of New Mexico, Albuquerque, NM, USA.
3
Department of Electrical &Computer Engineering, University of New Mexico, Albuquerque, NM, USA; The Mind Research Network, Albuquerque, NM, USA.
4
Department of Psychology, University of New Mexico, Albuquerque, NM, USA; The Mind Research Network, Albuquerque, NM, USA.

Abstract

Cognitive operations often require integration of information. Previous studies have shown that, integration of information in working memory recruits frontopolar cortex (FPC). In this fMRI study, we sought to reveal neural mechanisms of FPC underlying the integration of information during arithmetic tasks. We compared a condition requiring manipulation of two features of an item held in working memory with manipulation of one feature. The results showed that, FPC was equally recruited in both conditions, while dorsolateral prefrontal cortex (DLPFC) tended to be more activated when manipulating two features. We suggest that, FPC plays an integrative role and is recruited by the production of representations in accordance with task constraints, whereas DLPFC appears to be sensitive to processing demands induced by the manipulation of information.

KEYWORDS:

Dorsolateral prefrontal cortex; Frontopolar cortex; Functional MRI; Integration; Manipulation; Working memory

PMID:
25818331
PMCID:
PMC4495662
DOI:
10.1016/j.neulet.2015.03.044
[Indexed for MEDLINE]
Free PMC Article

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