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Psychol Med. 2015 Aug;45(11):2285-94. doi: 10.1017/S0033291715000239. Epub 2015 Mar 30.

Resilience and corpus callosum microstructure in adolescence.

Author information

1
INSERM,UMR 1000,Research unit Imaging and Psychiatry,Service Hospitalier Frédéric Joliot,Orsay,France.
2
King's College, London Institute of Psychiatry,London,UK.
3
Psychiatry Department,University of Tampere,School of Medicine, Tampere,Finland.
4
Department of Cognitive and Clinical Neuroscience,Central Institute of Mental Health,Medical Faculty Mannheim/Heidelberg University,Germany.
5
Neurospin,Saclay,France.
6
Universitaetsklinikum Hamburg Eppendorf,Hamburg,Germany.
7
Department of Child and Adolescent Psychiatry and Psychotherapy,Central Institute of Mental Health,Medical Faculty Mannheim/Heidelberg University,Germany.
8
Institute of Neuroscience and Department of Psychiatry,School of Medicine,Trinity College Dublin,Dublin,Ireland.
9
Department of Psychiatry and Psychotherapy,Campus Charité Mitte,Charité-Universitätsmedizin,Berlin,Germany.
10
Institute of Neuroscience,Trinity College Dublin,Dublin,Ireland.
11
Physikalisch-Technische Bundesanstalt (PTB),Braunschweig und Berlin,Germany.
12
Department of Child and Adolescent Psychiatry,Psychosomatics and Psychotherapy,Charité-Universitätsmedizin,Berlin,Germany.
13
School of Psychology,University of Nottingham,UK.
14
Department of Physiology and Nutritional Sciences,The Hospital for Sick Children,University of Toronto,Toronto, ONT,Canada.
15
Department of Experimental Psychology,Behavioural and Clinical Neurosciences Institute,University of Cambridge,UK.
16
Department of Psychiatry and Psychotherapy,Technische Universität Dresden,Germany.

Abstract

BACKGROUND:

Resilience is the capacity of individuals to resist mental disorders despite exposure to stress. Little is known about its neural underpinnings. The putative variation of white-matter microstructure with resilience in adolescence, a critical period for brain maturation and onset of high-prevalence mental disorders, has not been assessed by diffusion tensor imaging (DTI). Lower fractional anisotropy (FA) though, has been reported in the corpus callosum (CC), the brain's largest white-matter structure, in psychiatric and stress-related conditions. We hypothesized that higher FA in the CC would characterize stress-resilient adolescents.

METHOD:

Three groups of adolescents recruited from the community were compared: resilient with low risk of mental disorder despite high exposure to lifetime stress (n = 55), at-risk of mental disorder exposed to the same level of stress (n = 68), and controls (n = 123). Personality was assessed by the NEO-Five Factor Inventory (NEO-FFI). Voxelwise statistics of DTI values in CC were obtained using tract-based spatial statistics. Regional projections were identified by probabilistic tractography.

RESULTS:

Higher FA values were detected in the anterior CC of resilient compared to both non-resilient and control adolescents. FA values varied according to resilience capacity. Seed regional changes in anterior CC projected onto anterior cingulate and frontal cortex. Neuroticism and three other NEO-FFI factor scores differentiated non-resilient participants from the other two groups.

CONCLUSION:

High FA was detected in resilient adolescents in an anterior CC region projecting to frontal areas subserving cognitive resources. Psychiatric risk was associated with personality characteristics. Resilience in adolescence may be related to white-matter microstructure.

KEYWORDS:

Adolescence; DAWBA; DTI; NEO-FFI; corpus callosum; resilience; tractography

PMID:
25817177
DOI:
10.1017/S0033291715000239
[Indexed for MEDLINE]

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