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Acta Clin Belg. 2015 Aug;70(4):244-50. doi: 10.1179/2295333715Y.0000000012. Epub 2015 Mar 27.

Barnidipine real-life tolerability in arterial hypertension: results from the BASIC-HT study.

Abstract

INTRODUCTION:

Blood pressure (BP) is generally poorly controlled in hypertensive patients. One cause is poor adherence to drugs, which can be improved by treatments combining good efficacy and tolerability. Barnidipine is a strong lipophilic calcium channel blocker (CCB) with efficacy similar to other dihydropyridines.

OBJECTIVE:

BASIC HT is an observational study in a large population of patients with essential hypertension to evaluate the tolerability of barnidipine in a real-life setting.

METHODS:

20479 patients were enrolled in the study. Tolerability and efficacy was assessed at 2 visits during a 3-month period. 20275 patients were included in the analysis.

RESULTS:

Adverse events were reported by 10.6% of the patients, leading to treatment discontinuation in 3%. Events were those expected with CCBs. The drop-out rate was 8%. Mean systolic and diastolic pressure decreased from 159.6 to 138.2 and from 92.5 to 81.7 mmHg.

CONCLUSION:

The decrease in BP, is probably due to stimulation of good adherence by barnidipine.

KEYWORDS:

Barnidipine,; Calcium channel blockers,; Hypertensive patient,; Observational study,; Persistence

PMID:
25816195
DOI:
10.1179/2295333715Y.0000000012
[Indexed for MEDLINE]

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