The effects of gene polymorphisms in angiotensin II receptors on pregnancy-induced hypertension and preeclampsia: a systematic review and meta-analysis

Hypertens Pregnancy. 2015 May;34(2):241-60. doi: 10.3109/10641955.2015.1009543. Epub 2015 Mar 27.

Abstract

Background: To assess whether the polymorphisms of angiotensin II type 1 and type 2 receptors (AT1R, AT2R) are associated with pregnancy-induced hypertension (PIH) and preeclampsia.

Methods: Studies were searched from PubMed, ISI Web of Science and HuGE Navigator.

Results: The A1166C polymorphism of AT1R, A1675G and C3123A polymorphisms of AT2R were analyzed. Significant association was found in recessive model (OR = 1.581, 95% confidence interval (CI): 1.054-2.371) and co-dominant (GG versus AG) model (OR = 1.900, 95%CI: 1.001-3.604) between the A1675G polymorphism and preeclampsia. No association was found between the other polymorphisms and PIH or preeclampsia.

Conclusions: The A1675G polymorphism might be associated with preeclampsia, but the A1166C and C3123A polymorphisms had no effect on PIH or preeclampsia.

Keywords: Angiotensin II receptors; Genetics; Meta-analysis; Preeclampsia; Pregnancy-induced hypertension (PIH)..

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Confidence Intervals
  • Female
  • Humans
  • Hypertension, Pregnancy-Induced / genetics*
  • Polymorphism, Single Nucleotide*
  • Pre-Eclampsia / genetics*
  • Pregnancy
  • Receptor, Angiotensin, Type 1 / genetics*
  • Receptor, Angiotensin, Type 2 / genetics*

Substances

  • AGTR1 protein, human
  • Receptor, Angiotensin, Type 1
  • Receptor, Angiotensin, Type 2