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Cell. 2015 Mar 26;161(1):133-45. doi: 10.1016/j.cell.2015.02.023.

Neural control of energy balance: translating circuits to therapies.

Author information

1
Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9077, USA. Electronic address: laurent.gautron@utsouthwestern.edu.
2
Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9077, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9077, USA.
3
Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9077, USA; Department of Neuroscience, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9077, USA. Electronic address: kevin.williams@utsouthwestern.edu.

Abstract

Recent insights into the neural circuits controlling energy balance and glucose homeostasis have rekindled the hope for development of novel treatments for obesity and diabetes. However, many therapies contribute relatively modest beneficial gains with accompanying side effects, and the mechanisms of action for other interventions remain undefined. This Review summarizes current knowledge linking the neural circuits regulating energy and glucose balance with current and potential pharmacotherapeutic and surgical interventions for the treatment of obesity and diabetes.

PMID:
25815991
PMCID:
PMC4392840
DOI:
10.1016/j.cell.2015.02.023
[Indexed for MEDLINE]
Free PMC Article
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