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Cell. 2015 Mar 26;161(1):93-105. doi: 10.1016/j.cell.2015.02.021.

I'm eating for two: parental dietary effects on offspring metabolism.

Author information

1
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: oliver.rando@umassmed.edu.
2
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address: rsimmons@mail.med.upenn.edu.

Abstract

It has long been understood that the pathogenesis of complex diseases such as diabetes includes both genetic and environmental components. More recently, it has become clear that not only does an individual's environment influence their own metabolism, but in some cases, the environment experienced by their parents may also contribute to their risk of metabolic disease. Here, we review the evidence that parental diet influences metabolic phenotype in offspring in mammals and provide a current survey of our mechanistic understanding of these effects.

PMID:
25815988
PMCID:
PMC4465102
DOI:
10.1016/j.cell.2015.02.021
[Indexed for MEDLINE]
Free PMC Article

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