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Cell. 2015 Mar 26;161(1):84-92. doi: 10.1016/j.cell.2015.03.015.

Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock.

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Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address:
Center for Epigenetics and Metabolism, Department of Biological Chemistry, U904 INSERM, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:


The circadian clock, a highly specialized, hierarchical network of biological pacemakers, directs and maintains proper rhythms in endocrine and metabolic pathways required for organism homeostasis. The clock adapts to environmental changes, specifically daily light-dark cycles, as well as rhythmic food intake. Nutritional challenges reprogram the clock, while time-specific food intake has been shown to have profound consequences on physiology. Importantly, a critical role in the clock-nutrition interplay appears to be played by the microbiota. The circadian clock appears to operate as a critical interface between nutrition and homeostasis, calling for more attention on the beneficial effects of chrono-nutrition.

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