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Ann Clin Transl Neurol. 2015 Mar;2(3):295-301. doi: 10.1002/acn3.164. Epub 2015 Jan 14.

Histopathology and clinical course of MOG-antibody-associated encephalomyelitis.

Author information

1
Institute of Clinical Neuroimmunology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.
2
Department of Radiology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.
3
Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg 06120, Halle, Germany.
4
Department of Neurology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.
5
Department of Neuropathology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.
6
Institute of Clinical Neuroimmunology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany ; Munich Cluster for Systems Neurology (SyNergy) Munich, Germany.
7
Department for Neuroimmunology, Center for Brain Research Vienna, Austria.

Abstract

We present histological, MRI, and clinical features of an adult patient with relapsing encephalomyelitis and antibodies against myelin oligodendrocyte glycoprotein (MOG). Furthermore, we report molecular details of the recognized epitope that is specific for human MOG. A brain biopsy revealed multiple sclerosis (MS)-type II pathology. Some features overlapped with both MS and neuromyelitis optica spectrum disorders (NMOSD), whereas others were distinct from both MS and NMOSD. Immunoadsorption and rituximab induced clinical stabilization. This case contributes a new, so far missing link in the emerging spectrum of MOG-antibody-associated encephalomyelitis.

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