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Ann Clin Transl Neurol. 2015 Mar;2(3):289-94. doi: 10.1002/acn3.163. Epub 2015 Feb 16.

Cannabinoid agonist rescues learning and memory after a traumatic brain injury.

Author information

1
Alberta Children's Hospital Research Institute, University of Calgary Calgary, Alberta, Canada.
2
Regeneration Unit in Neurobiology Core Facility, University of Calgary Calgary, Alberta, Canada.
3
Alberta Children's Hospital Research Institute, University of Calgary Calgary, Alberta, Canada ; Department of Biology, University of Hawai'i at Hilo Hilo, Hawai'i, USA.

Abstract

Traumatic brain injury can cause persistent challenges including problems with learning and memory. Previous studies suggest that the activation of the cannabinoid 1 receptor after a traumatic brain injury could be beneficial. We tested the hypothesis that posttraumatic brain injury administration of a cannabinoid 1 receptor agonist can rescue deficits in learning and memory. Young adult male rats were subjected to a moderately severe controlled cortical impact brain injury, with a subset given postinjury i.p. injections of a cannabinoid receptor agonist. Utilizing novel object recognition and the morris water task, we found that the brain-injured animals treated with the agonist showed a marked recovery.

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