Kinetic properties of the plasma membrane Na+-H+ exchanger

Annu Rev Physiol. 1985:47:545-60. doi: 10.1146/annurev.ph.47.030185.002553.

Abstract

The plasma membrane Na+-H+ exchanger is a ubiquitous transport system that participates in diverse cell functions involving the cellular uptake of Na+ or extrusion of H+. It has a tightly coupled 1:1 stoichiometry, has affinity for Li+ and NH+4 in addition to Na+ and H+, and can function in multiple amiloride-sensitive exchange modes involving these cations. These general transport properties may be explained by kinetic models involving either cation-hydroxyl cotransport or actual cation-proton exchange. The most important kinetic property of the Na+-H+ exchanger is its greater than first-order dependence on [H+]i. This property enables the Na+-H+ exchanger to play an important role in the regulation of intracellular pH.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport, Active
  • Carrier Proteins / metabolism*
  • Cell Membrane / metabolism*
  • Cell Membrane Permeability
  • Humans
  • Hydrogen-Ion Concentration
  • Ion Channels / metabolism
  • Ion Exchange
  • Kinetics
  • Models, Chemical
  • Protons
  • Sodium-Hydrogen Exchangers
  • Thermodynamics

Substances

  • Carrier Proteins
  • Ion Channels
  • Protons
  • Sodium-Hydrogen Exchangers