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Orient Pharm Exp Med. 2015;15(1):7-12. Epub 2014 Dec 5.

Anti-inflammatory effects of Cordyceps mycelium (Paecilomyces hepiali, CBG-CS-2) in Raw264.7 murine macrophages.

Author information

1
Department of Dental Pharmacology and Wonkwang Dental Research Institute, School of Dentistry, Wonkwang University, Iksan, 570-749 Republic of Korea.
2
Clinical Trial Center for Functional Foods (CTCF2), Chonbuk National University Hospital, 20, Geonjiro, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-712 Republic of Korea.
3
Healthcare Claims & Management Inc., 758, Baekjedaero, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-832 Republic of Korea.
4
CHEBIGEN Inc., 111-18, Wonjangdong-gil, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-360 Republic of Korea.
5
Department of Pharmacology, Chonbuk National University Medical School, 567 Baekje-daero, deokjin-gu, Jeonju-si, Jeollabuk-do 561-756 Republic of Korea.
6
Clinical Trial Center for Functional Foods (CTCF2), Chonbuk National University Hospital, 20, Geonjiro, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-712 Republic of Korea ; Department of Pharmacology, Chonbuk National University Medical School, 567 Baekje-daero, deokjin-gu, Jeonju-si, Jeollabuk-do 561-756 Republic of Korea.

Abstract

Cordyceps (CS) is a traditional Chinese herb with various biological effects that include immune modulation. CBG-CS-2 is a strain, Paecilomyces hepiali, of the Cordyceps spp. The anti-inflammatory effects of CBG-CS-2 were investigated. The water-soluble fraction of CBG-CS-2 has high anti-inflammatory activity in LPS-induced Raw264.7 macrophages. We tested the role of CBG-CS-2 on the anti-inflammation cascade in LPS-stimulated Raw264.7 cells. CBG-CS-2 significantly decreased NO production, iNOS expression, and pro-inflammatory cytokine secretion in a dose-dependent manner. To investigate the mechanism by which CBG-CS-2 inhibits NO, iNOS, and pro-inflammatory cytokines, we examined the activities of NF-κB and AP-1 in LPS-activated macrophages. The results demonstrate that CBG-CS-2 suppresses the production and expression of NO, iNOS, and pro-inflammatory cytokines in LPS-activated macrophages via inhibition of NF-κB and AP-1, which may play an important role in inflammation. These findings suggest that CBG-CS-2 has modulatory effects on the inflammatory system in macrophages, and that it can serve as a useful anti-inflammatory dietary supplement or drug.

KEYWORDS:

Anti-inflammation; CBG-CS-2; Cordyceps; Paecilomyces hepiali

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