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Tissue Eng Part B Rev. 2015 Aug;21(4):393-410. doi: 10.1089/ten.TEB.2015.0014. Epub 2015 Apr 30.

Regenerative Medicine Strategies for Esophageal Repair.

Author information

1
1 McGowan Institute for Regenerative Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
2
2 School of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
3
3 Department of Bioengineering, University of Pittsburgh , Pittsburgh, Pennsylvania.
4
4 Department of Surgery, University of Pittsburgh , Pittsburgh, Pennsylvania.

Abstract

Pathologies that involve the structure and/or function of the esophagus can be life-threatening. The esophagus is a complex organ comprising nonredundant tissue that does not have the ability to regenerate. Currently available interventions for esophageal pathology have limited success and are typically associated with significant morbidity. Hence, there is currently an unmet clinical need for effective methods of esophageal repair. The present article presents a review of esophageal disease along with the anatomic and functional consequences of each pathologic process, the shortcomings associated with currently available therapies, and the latest advancements in the field of regenerative medicine with respect to strategies for esophageal repair from benchtop to bedside.

PMID:
25813694
PMCID:
PMC4533024
DOI:
10.1089/ten.TEB.2015.0014
[Indexed for MEDLINE]
Free PMC Article

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