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Arch Virol. 2015 Jun;160(6):1415-20. doi: 10.1007/s00705-015-2393-3. Epub 2015 Mar 27.

In vitro antiviral activity of germacrone against porcine parvovirus.

Author information

1
Guangdong Provincial Key Lab of Agro-animal Genomics and Molecular Breeding, College of Animal Science, National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China, scauchenye@163.com.

Abstract

Porcine parvovirus (PPV) infections can lead to significant losses to the swine industry by causing reproductive failure in pigs. Germacrone has been reported to efficiently suppress the replication of influenza virus. In this report, the antiviral activity of germacrone on PPV in swine testis (ST) cells was investigated. Here, we show for the first time that germacrone protects cells from PPV infection and suppresses the synthesis of viral mRNA and protein. Furthermore, we show that germacrone inhibits PPV replication at an early stage in a dose-dependent manner. These findings suggest that germacrone is a potential candidate for anti-PPV therapy.

PMID:
25813663
DOI:
10.1007/s00705-015-2393-3
[Indexed for MEDLINE]

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