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Virology. 2015 May;479-480:609-18. doi: 10.1016/j.virol.2015.02.038. Epub 2015 Mar 23.

Viral activation of cellular metabolism.

Author information

1
Department of Microbiology and program in Molecular and Cellular Biology, University of Washington, Seattle WA, USA.
2
Department of Microbiology and program in Molecular and Cellular Biology, University of Washington, Seattle WA, USA. Electronic address: Lagunoff@u.washington.edu.

Abstract

To ensure optimal environments for their replication and spread, viruses have evolved to alter many host cell pathways. In the last decade, metabolomic studies have shown that eukaryotic viruses induce large-scale alterations in host cellular metabolism. Most viruses examined to date induce aerobic glycolysis also known as the Warburg effect. Many viruses tested also induce fatty acid synthesis as well as glutaminolysis. These modifications of carbon source utilization by infected cells can increase available energy for virus replication and virion production, provide specific cellular substrates for virus particles and create viral replication niches while increasing infected cell survival. Each virus species also likely requires unique metabolic changes for successful spread and recent research has identified additional virus-specific metabolic changes induced by many virus species. A better understanding of the metabolic alterations required for the replication of each virus may lead to novel therapeutic approaches through targeted inhibition of specific cellular metabolic pathways.

KEYWORDS:

Fatty acid synthesis; Glutaminolysis; Glycolysis; Metabolism; Metabolomics; Virus

PMID:
25812764
PMCID:
PMC4424078
DOI:
10.1016/j.virol.2015.02.038
[Indexed for MEDLINE]
Free PMC Article

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