Abstract
The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that the vaccine virus does not pose a risk of dissemination in pigs.
Keywords:
Ebola virus; VSV; VSV vaccine; pigs; recombinant VSV–Ebola virus vaccine vector; safety; vaccines; vesicular stomatitis viruses; viruses; zoonoses.
Publication types
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Research Support, N.I.H., Intramural
MeSH terms
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Animals
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Antibodies, Viral / blood
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Antibodies, Viral / immunology
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DNA, Recombinant*
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Ebolavirus / genetics*
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Genetic Vectors / administration & dosage
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Genetic Vectors / adverse effects*
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Genetic Vectors / genetics*
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Genetic Vectors / immunology
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Immunization
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Immunoglobulin G / blood
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Immunoglobulin G / immunology
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Swine
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Vesicular stomatitis Indiana virus / genetics*
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Viral Vaccines / administration & dosage
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Viral Vaccines / adverse effects*
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Viral Vaccines / genetics*
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Viral Vaccines / immunology
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Virus Replication
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Virus Shedding
Substances
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Antibodies, Viral
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DNA, Recombinant
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Immunoglobulin G
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Viral Vaccines