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Analyst. 2015 Jun 21;140(12):3897-909. doi: 10.1039/c5an00178a. Epub 2015 Mar 26.

Applications of coherent Raman scattering microscopies to clinical and biological studies.

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Leibniz Institute of Photonic Technology, Albert-Einstein-Stra├če 9, 07745 Jena, Germany.


Coherent anti-Stokes Raman scattering (CARS) microscopy and stimulated Raman scattering (SRS) microscopy are two nonlinear optical imaging modalities that are at the frontier of label-free and chemical specific biological and clinical diagnostics. The applications of coherent Raman scattering (CRS) microscopies are multifold, ranging from investigation of basic aspects of cell biology to the label-free detection of pathologies. This review summarizes recent progress of biological and clinical applications of CRS between 2008 and 2014, covering applications such as lipid droplet research, single cell analysis, tissue imaging and multiphoton histopathology of atherosclerosis, myelin sheaths, skin, hair, pharmaceutics, and cancer and surgical margin detection.

[Indexed for MEDLINE]

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