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Sci Transl Med. 2015 Mar 25;7(280):280rv2. doi: 10.1126/scitranslmed.aaa6853.

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation.

Author information

1
Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA.
2
Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.Immune Tolerance Network, Massachusetts General Hospital, Boston, MA 02114, USA. Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.Immune Tolerance Network, Massachusetts General Hospital, Boston, MA 02114, USA. blaza001@umn.edu lturka@partners.org.
3
Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA. blaza001@umn.edu lturka@partners.org.

Abstract

Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.

PMID:
25810312
PMCID:
PMC4425354
DOI:
10.1126/scitranslmed.aaa6853
[Indexed for MEDLINE]
Free PMC Article

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