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Angew Chem Int Ed Engl. 2015 May 11;54(20):5939-42. doi: 10.1002/anie.201500252. Epub 2015 Mar 24.

A Signal-Passing DNA-Strand-Exchange Mechanism for Active Self-Assembly of DNA Nanostructures.

Author information

1
Department of Chemistry, New York University, New York, NY 10003 (USA); Current Address: Department of Materials Science and Engineering, Boise State University, Boise, ID 83725 (USA). jenniferepadilla@boisestate.edu.

Abstract

DNA nanostructured tiles play an active role in their own self-assembly in the system described herein whereby they initiate a binding event that produces a cascading assembly process. We present DNA tiles that have a simple but powerful property: they respond to a binding event at one end of the tile by passing a signal across the tile to activate a binding site at the other end. This action allows sequential, virtually irreversible self-assembly of tiles and enables local communication during the self-assembly process. This localized signal-passing mechanism provides a new element of control for autonomous self-assembly of DNA nanostructures.

KEYWORDS:

DNA structures; DNA tiles; nanotechnology; self-assembly; strand displacement

PMID:
25810302
PMCID:
PMC4527968
DOI:
10.1002/anie.201500252
[Indexed for MEDLINE]
Free PMC Article

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