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Environ Microbiol. 2015 Nov;17(11):4148-63. doi: 10.1111/1462-2920.12849. Epub 2015 Jun 25.

Biogenesis of Pseudomonas aeruginosa type IV pili and regulation of their function.

Author information

1
Department of Biochemistry and Biomedical Sciences, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada.
2
Program in Molecular Structure & Function, The Hospital for Sick Children, Toronto, ON, Canada.
3
Department of Biochemistry, University of Toronto, Toronto, ON, Canada.

Abstract

Type IV pili (T4P) are bacterial virulence factors involved in a wide variety of functions including deoxyribonucleic acid uptake, surface attachment, biofilm formation and twitching motility. While T4P are common surface appendages, the systems that assemble them and the regulation of their function differ between species. Pseudomonas aeruginosa, Neisseria spp. and Myxococcus xanthus are common model systems used to study T4P biology. This review focuses on recent advances in P. aeruginosa T4P structural biology, and the regulatory pathways controlling T4P biogenesis and function.

PMID:
25808785
DOI:
10.1111/1462-2920.12849
[Indexed for MEDLINE]

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