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Environ Sci Technol. 2015 Apr 21;49(8):5107-14. doi: 10.1021/acs.est.5b00234. Epub 2015 Apr 6.

Higher PBDE serum concentrations may be associated with feline hyperthyroidism in Swedish cats.

Author information

1
†Analytical and Toxicological Chemistry Unit, Department of Environmental Science and Analytical Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden.
2
‡Department of Clinical Sciences, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden.
3
§Swedish Museum of Natural History, Frescativägen 40, SE-114 18 Stockholm, Sweden.
4
∥Swedish Toxicology Sciences Research Center (Swetox), Forskargatan 20, SE-151 36 Södertälje, Sweden.

Abstract

Serum from 82 individual cats was analyzed for decabromobiphenyl (BB-209), polybrominated diphenyl ethers (PBDEs), hydroxylated PBDEs (OH-PBDEs), and 2,4,6-TBP in order to study differences in body burden between healthy and sick cats diagnosed with Feline Hyperthyroidism (FH). Within the study group, 60 of these cats had a euthyroid (n = 23) or hyperthyroid (n = 37) status, all of which were used in the comparison. This study shows that hyperthyroid compared to euthyroid cats have higher serum concentrations for some of the investigated PBDEs (BDE-99, BDE-153, and BDE-183) and CB-153 on a fat weight basis. Further, it is intriguing, and beyond explanation, why the flame retardant BB-209 (discontinued in 2000) is present in all of the cat serum samples in concentrations similar to BDE-209. Median BDE-47/-99 ratios are 0.47 and 0.32 for healthy and euthyroid cats, respectively, which differs significantly from Swedes, where the ratio is 3.5. Another important finding is the occurrence of very low levels or the absence of hydroxylated PBDE metabolites in the cats. In addition, the major OH-PBDE, 6-OH-BDE47, is likely of natural origin, probably ingested via cat food. The statistics indicate an association between elevated PBDE concentrations in the cats and FH.

PMID:
25807268
DOI:
10.1021/acs.est.5b00234
[Indexed for MEDLINE]

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