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JAMA Dermatol. 2015 Jun;151(6):635-7. doi: 10.1001/jamadermatol.2015.0175.

Narrowband UV-B Phototherapy for Steroid-Refractory Sclerotic Chronic Cutaneous Graft-vs-Host Disease.

Author information

1
Keck School of Medicine, University of Southern California, Los Angeles.
2
Michigan State University College of Human Medicine, East Lansing.
3
University of California, Irvine, School of Medicine, Irvine.
4
Division of Hematologic Malignancies and Blood and Marrow Transplantation, Department of Medicine, University of California, San Francisco.
5
Psoriasis Treatment Center, University of California, San Francisco.

Erratum in

Abstract

IMPORTANCE:

Chronic graft-vs-host disease (GVHD) affects 50% to 70% of patients who receive allogeneic hematopoietic cell transplants (HCTs), and the skin is the most common site of involvement. Chronic cutaneous GVHD can present with sclerotic or nonsclerotic changes of the skin and often requires treatment with systemic immunosuppressants, extracorporeal photopheresis, or phototherapy. We describe the first reported case, to our knowledge, of the effective treatment of sclerotic chronic cutaneous GVHD with narrowband UV-B (NB UV-B) phototherapy.

OBSERVATIONS:

A woman in her 40s presented with sclerotic chronic GVHD of the skin 6 years after HCT for treatment of chronic myelogenous leukemia. The patient's cutaneous disease progressed despite treatment with prednisone and oral tacrolimus. The patient was initiated on NB UV-B phototherapy 3 times per week, resulting in clinically significant improvement of cutaneous lesions over the first 2 months. The NB UV-B regimen allowed for a reduction of prednisone dose and continued control of cutaneous GVHD over 6 months of therapy.

CONCLUSIONS AND RELEVANCE:

Our case report describes the successful use of NB UV-B phototherapy for the treatment of sclerotic chronic cutaneous GVHD. Further study should be performed to evaluate the effectiveness of this therapeutic modality for patients with sclerotic chronic cutaneous GVHD.

PMID:
25806783
DOI:
10.1001/jamadermatol.2015.0175
[Indexed for MEDLINE]

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