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Front Oncol. 2015 Mar 10;5:53. doi: 10.3389/fonc.2015.00053. eCollection 2015.

Single cell transcriptomics: methods and applications.

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Faculty of Engineering, Institute of Nanotechnology, Bar-Ilan University , Ramat Gan , Israel.


Traditionally, gene expression measurements were performed on "bulk" samples containing populations of thousands of cells. Recent advances in genomic technology have made it possible to measure gene expression in hundreds of individual cells at a time. As a result, cellular properties that were previously masked in "bulk" measurements can now be observed directly. In this review, we will survey emerging technologies for single cell transcriptomics, and describe how they are used to study complex disease such as cancer, as well as other biological phenomena such as tissue regeneration, embryonic development, and immune response.


FISH; RNA sequencing; gene expression; qPCR; single cell

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