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World J Gastroenterol. 2015 Mar 21;21(11):3174-83. doi: 10.3748/wjg.v21.i11.3174.

Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies.

Author information

1
Sahil Gambhir, Dinesh Vyas, Michael Hollis, Apporva Aekka, Department of Surgery, College of Human Medicine, Michigan State University, East Lansing, MI 48912, United States.

Abstract

Nuclear factor kappa B (NF-κB) has an established role in the regulation of innate immunity and inflammation. NF-κB is also involved in critical mechanisms connecting inflammation and cancer development. Recent investigations suggest that the NF-κB signaling cascade may be the central mediator of gastrointestinal malignancies including esophageal, gastric and colorectal cancers. This review will explore NF-κB's function in inflammation-associated gastrointestinal malignancies, highlighting its oncogenic contribution to each step of carcinogenesis. NF-κB's role in the inflammation-to-carcinoma sequence in gastrointestinal malignancies warrants stronger emphasis upon targeting this pathway in achieving greater therapeutic efficacy.

KEYWORDS:

Gastrointestinal cancer; Inflammation; Nuclear factor kappa B

PMID:
25805923
PMCID:
PMC4363746
DOI:
10.3748/wjg.v21.i11.3174
[Indexed for MEDLINE]
Free PMC Article

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